https://asylumprojects.org/index.php?title=Hurler_syndrome&feed=atom&action=historyHurler syndrome - Revision history2024-03-28T20:20:35ZRevision history for this page on the wikiMediaWiki 1.30.0https://asylumprojects.org/index.php?title=Hurler_syndrome&diff=12738&oldid=prevThomasp94: Created page with ''''Hurler syndrome''', also known as mucopolysaccharidosis type I (MPS I), Hurler's disease, also gargoylism, is a genetic disorder that results in the buildup of glycosa…'2011-11-22T19:11:59Z<p>Created page with ''''Hurler syndrome''', also known as <a href="/index.php/mucopolysaccharidosis" class="mw-redirect" title="mucopolysaccharidosis">mucopolysaccharidosis</a> type I (MPS I), Hurler's disease, also gargoylism, is a <a href="/index.php/genetic_disorder" class="mw-redirect" title="genetic disorder">genetic disorder</a> that results in the buildup of glycosa…'</p>
<p><b>New page</b></p><div>'''Hurler syndrome''', also known as [[mucopolysaccharidosis]] type I (MPS I), Hurler's disease, also gargoylism, is a [[genetic disorder]] that results in the buildup of glycosaminoglycans (formerly known as mucopolysaccharides) due to a deficiency of alpha-L iduronidase, an enzyme responsible for the degradation of mucopolysaccharides in lysosomes. :544 Without this enzyme, a buildup of heparan sulfate and dermatan sulfate occurs in the body. Symptoms appear during childhood and early death can occur due to organ damage.<br />
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MPS I is divided into three subtypes based on severity of symptoms. All three types result from an absence of, or insufficient levels of, the enzyme α-L-iduronidase. MPS I H or Hurler syndrome is the most severe of the MPS I subtypes. The other two types are MPS I S or Scheie syndrome and MPS I H-S or Hurler-Scheie syndrome.<br />
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Hurler syndrome is often classified as a lysosomal storage disease, and is clinically related to Hunter Syndrome. Hunter is X-linked while Hurler is autosomal recessive.<br />
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It is named for [[Gertrud Hurler]].<ref>http://en.wikipedia.org/wiki/Gargoylism</ref><br />
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== References ==<br />
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[[Category:Terminology]]</div>Thomasp94